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George Reeves brought the superhero to life in the 1951 film "Superman and the Mole Men." One year later, he reprised his role for the television series "Adventures of Superman," which ran through 1958.
Reeve donned Superman's cape (and Clark Kent's thick glasses) for the 1978 film "Superman" and its three sequels, "Superman II," Superman III, and "Superman IV: The Quest for Peace."
Between 1993 and 1997, Dean Cain starred as Superman opposite Teri Hatcher's Lois Lane in the ABC series "Lois & Clark: The New Adventures of Superman."
"Smallville" starred Tom Welling as a young Clark Kent attending high school in the fictional town of Smallville, Kansas, before eventually finding a job at The Daily Planet in Metropolis. Welling's tenure as the superhero lasted for 10 years — longer than any other actor who played the role.
Brandon Routh was chosen to don the blue tights in 2006's "Superman Returns," a modern-day reboot of (and somewhat-sequel to) 1978's "Superman" and 1980's "Superman II."